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dronedarone will enhance the degree or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
Paradoxical reactions may perhaps take place together with hallucinations, intense behavior, and psychoses; dinscontinue use if reactions happen
Diazepam may make you drowsy and slow your response moments. Due to this, it’s critical that you choose to don’t generate or run significant machinery whenever you get it.
efavirenz will lessen the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Keep track of Closely (1)mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Mitotane is a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for achievable dosage changes.
tazemetostat will minimize the level or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
lorlatinib will lower the level or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
lumefantrine will lower the level or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Keep track of for indications of respiratory melancholy That could be larger than if not anticipated and decrease muscle relaxant dosage as necessary.Major - Use Different (1)buprenorphine, extended-acting injection and diazepam the two maximize sedation. Stay away from or Use Alternate Drug. Restrict use to people for whom different cure possibilities are inadequate
The prescriber need to be confident from historical stories and/or private observations that the affected individual exhibits identifiable properties of seizure cluster which might be distinguished with the individual’s usual seizure exercise via the caregiver who will be chargeable for administering diazepam rectal gel
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diazepam and olopatadine intranasal each raise sedation. Stay website away from or Use Alternate Drug. Coadministration raises hazard of CNS depression, which may lead to additive impairment of psychomotor functionality and result in daytime impairment.
Lively metabolites: N-desmethyldiazepam and temazepam, that are equally additional metabolized to oxazepam; mostly eradicated by glucuronidation